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Publications

FAST Proteins (Selected)

Fusogenic Reoviruses and Their Fusion-Associated Small Transmembrane (FAST) Proteins.

Duncan R. Annu Rev Virol. 2019. PMID: 31283438 Review.


Reovirus FAST proteins: virus-encoded cellular fusogens. 

Ciechonska M, Duncan R. Trends Microbiol. 2014 Dec;22(12):715-24. doi:

10.1016/j.tim.2014.08.005. Epub 2014 Sep 19. PMID: 25245455.


Cell-cell membrane fusion induced by p15 fusion-associated small transmembrane (FAST) protein requires a novel fusion peptide motif containing a myristoylated polyproline type II helix.

Top D, et al. J Biol Chem. 2012. PMID: 22170056


Enhanced fusion pore expansion mediated by the trans-acting Endodomain of the reovirus FAST proteins.

Top D, et al. PLoS Pathog. 2009. PMID: 19266079


Reovirus FAST protein transmembrane domains function in a modular, primary sequence-independent manner to mediate cell-cell membrane fusion.

Clancy EK, et al. J Virol. 2009. PMID: 19129451


The p14 fusion-associated small transmembrane (FAST) protein effects membrane fusion from a subset of membrane microdomains.

Corcoran JA, et al. J Biol Chem. 2006. PMID: 16936325

Fusogenix PLV

Healthspan Extension through Innovative Genetic Medicines (vol 150, pg 49S, 2022)

H Garcia, D Brown, M Scholz, JD Lewis

PLASTIC AND RECONSTRUCTIVE SURGERY 151 (1), 235-235



Scientific Abstracts & Presentations (Selected)

 



Tracking p14-induced cellular fusion through the visualization of cellular membranes and nuclei

M Cuthbert - 2017 - scholar.archive.org 

Patents

Recombinant polypeptides for membrane fusion and uses thereof

R Duncan, EK Clancy, J Lewis, RJ De Antueno, RL Nesbitt

US Patent 10,227,386


PROTEOLIPID VESICLES FORMULATED WITH FUSION-ASSOCIATED SMALL TRANSMEMBRANE PROTEINS

JD Lewis, A Raturi

US Patent App. 18/029,823


 Fusogenic lipid nanoparticles for target cell-specific production of a therapeutic protein

MR Scholz, JD Lewis, GC Hudson

US Patent 11,603,543


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